"Lay the Favorite" follows unpredictable dreamer Beth (Rebecca Hall) as she goes from in-home stripper in Tallahassee to gambler's assistant in Las Vegas, working for Dink (Bruce Willis), one of the most successful sports gamblers in the business. She takes to the work like a natural, but makes the risky bet of falling for Dink, much to the chagrin of his retired showgirl wife Tulip (Catherine Zeta-Jones). That bet goes south, and a triangular war ensues.
Against Dink's protests, Beth goes to work for the flamboyant, unstable Rosie who runs a less-than-legal operation in New York City, then for his doomed hyper-speed online sportsbook in the betting Babylon that is Curacao. When Beth's risky gambles result in her innocent boyfriend Jeremy (Joshua Jackson) threatened with prison, she must reunite with Dink, face up to the fearsome Tulip, risk jail, and return to New York City to confront her responsibilities. Can she beat the odds and win the day?