A volunteer home care worker, Nishina Rika (Okina), enters the home of a bed-ridden patient and discovers a strange ghostly presence lurking behind a door sealed with duct tape. Her discovery unleashes a horrible evil which baffles police investigators, who find that a whole series of people have gone missing from this particular house. Further investigation leads to Izutni Toyama (Uehara), a former detective who handled the case of a man who murdered his wife in the house, but whose son was never found. But when the angry "Ju-On" spirit of vengeance that has infected the house reaches beyond its boundaries to kill Toyama and his daughter, Rika realizes that the horror is spreading. Worse, unless something is done about it, she feels she may become the angry spirit's next victim!