From the Pulitzer Prize-winning author of "The Hours" comes a story that chronicles a dozen years in the lives of two best friends who couldn't be more different. From suburban Cleveland in the 60s, to New York City in the 80s, where they meet an older woman, the film charts a journey of trials, triumphs, loves and losses. Now the question is: can they navigate the unusual triangle they've created and hold their friendship together?

A volunteer home care worker, Nishina Rika (Okina), enters the home of a bed-ridden patient and discovers a strange ghostly presence lurking behind a door sealed with duct tape. Her discovery unleashes a horrible evil which baffles police investigators, who find that a whole series of people have gone missing from this particular house. Further investigation leads to Izutni Toyama (Uehara), a former detective who handled the case of a man who murdered his wife in the house, but whose son was never found. But when the angry "Ju-On" spirit of vengeance that has infected the house reaches beyond its boundaries to kill Toyama and his daughter, Rika realizes that the horror is spreading. Worse, unless something is done about it, she feels she may become the angry spirit's next victim!