Ben Stiller portrays risk-averse Reuben Feffer, whose best-laid plans for life and love zoom wildly off track when his wife (Messing) dumps him on their honeymoon for a scuba instructor (Azaria). Stunned, humiliated and in the grip of acute indigestion, Reuben plans to play it safer than ever. But a chance encounter with an adventure-craving, globe-trotting friend from middle school (Aniston) shoots him into a whirlwind of extreme sports, spicy foods, ferrets, salsa dancing and living in the moment.

Biker Cary Ford (Henderson) has returned to his hometown to reunite with his girlfriend Shane (Mazur) and take care of a little unfinished business. When he skipped town months ago, Ford was in possession of several motorcycles belonging to Henry (Schulze), a ruthless drug dealer and leader of the Hellions biker gang. Now Henry's putting the squeeze on Ford in an attempt to retrieve the bikes, which have something a little more valuable than gas in their tanks. When Ford is less than willing to cooperate, Henry frames him for the murder of Junior, younger brother of Trey (Cube), the fearsome leader of the Reapers motorcycle gang. With the help of his loyal buddies Dalton (Hernandez) and Val (Yun Lee), Ford must outrun an FBI agent (Scott) who's hot on his trail while eluding both the misinformed Trey, hell-bent on revenge, and the callous Henry, who's dead-set on getting back what is rightfully his. Racing across the desert in a perilous attempt to prove his innocence and convince Shan...